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5-Hydroxytryptaime induces cyclooxygenase-2 in rat vascular smooth muscle cells: Mechanisms involving Src, PKC and MAPK activation

✍ Scribed by Takuji Machida; Misa Ohta; Akina Onoguchi; Kenji Iizuka; Mio Sakai; Masaru Minami; Masahiko Hirafuji

Book ID: 113589179
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 976 KB
Volume: 656
Category: Article
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2010.12.044

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## Abstract Sphingosine 1‐phosphate (S1P) has been shown to regulate smooth muscle cell proliferation, migration, and vascular maturation. S1P increases the expression of several proteins including COX‐2 in vascular smooth muscle cells (VSMCs) and contributes to arteriosclerosis. However, the mecha