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5-Hydroxyindoleacetic acid (5 HIAA) and homovanillic acid (HVA) following probenecid in acute psychotic patients treated with phenothiazines

✍ Scribed by Malcolm B. Bowers

Publisher
Springer
Year
1973
Tongue
English
Weight
542 KB
Volume
28
Category
Article
ISSN
0033-3158

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✦ Synopsis

Lumbar CSF 5tIIAh and ItVA were measured following probenecid administration in acute psychotic patients before and during treatment with phenottfiazines. Patients with more classical schizophrenic symptoms had higher values for 5 HIAA/ttVA than other psychotics, depressives, and inmate volunteers. Prior to treatment CSF 5 HIAA, but not HVA, correlated significantly with several clinical items related to psychotic disorganization. Phenothiazine treatment produced significant increases in CSF ttVA which could not be correlated with the dose of antipsychotic or antiparkinson drugs.

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