A total of 28 patients receiving cancer chemotherapy with cisplatin-containing regimens (70-120 mg/ m 2) participated in an evaluation of the efficacy and safety of GR38032F for the prevention of acute nausea and vomiting. GR38032F, a 5HT3 receptor antagonist, was given 30 min prior to cisplatin as
5-HT3receptor antagonistsvstraditional agents for the prophylaxis of postoperative nausea and vomiting
β Scribed by Peter S. Loewen; Carlo A. Marra; Peter J. Zed
- Publisher
- Springer-Verlag
- Year
- 2000
- Tongue
- French
- Weight
- 131 KB
- Volume
- 47
- Category
- Article
- ISSN
- 1496-8975
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
In a phase I study of BRL43694A, a 5HT3-receptor antagonist, a single dose of 40 micrograms/kg was given to 24 patients. All patients received cytostatic treatment expected to cause nausea and vomiting. During the first 24 h, 12 patients were completely protected from nausea and vomiting, 4 experien
Fifty six patients, with histologically confirmed cancer, who received highly emetogenic chemotherapy, were entered on a randomized double blind, low versus high dose, study of granisetron, a 5HT3 receptor antagonist. A single dose of intravenous granisetron protected the majority of patients from n