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5-HT2 receptor binding and 5-HT uptake in mouse brain: developmental changes and the relationship to audiogenic seizure susceptibility in DBA/2J mice

✍ Scribed by Salah P. Jazrawi; Roger W. Horton

Book ID
119101531
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
517 KB
Volume
45
Category
Article
ISSN
0165-3806

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## Abstract Prepulse inhibition (PPI), the reduction in acoustic startle produced when it is preceded by a weak prepulse stimulus, is impaired in schizophrenic patients. The DBA/2J mouse strain displayed deficient PPI and is therefore suggested as an experimental animal model for the loss of sensor