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5-FU tissue pharmacokinetics in a rat hepatoma model after intraarterial hepatic chemotherapy

✍ Scribed by M. Flentje; H. J. Sinn; G. Geelhaar; D. Flentje; P. Schlag

Book ID
112785603
Publisher
Springer-Verlag
Year
1986
Tongue
English
Weight
146 KB
Volume
111
Category
Article
ISSN
1432-1335

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## Abstract The nonlinear pharmacokinetics of capecitabine, a triple prodrug of 5‐FU preferentially activated in tumour tissues, was investigated in human cancer xenograft models. A physiologically based pharmacokinetic (PBPK) model integrating the activation process of capecitabine to 5‐FU and 5‐F