## Background: In the past 4 years, the weekly 24-hour infusion of high dose 5-fluorouracil (5-fu) and leucovorin in the treatment of patients with advanced gastric carcinoma has been prospectively studied at the authors' institution. this has enabled them to explore the possibility that the level
β¦ LIBER β¦
5-fluorouracil and uft-sensitive gastric carcinoma has a high level of thymidylate synthase
β Scribed by Yoshihiko Maehara; Tetsuya Kusumoto; Hiroki Kusumoto; Hideaki Anai; Yoshihisa Sakaguchi; Yuichiro Kido; Takeshi Okamura; Daisuke Korenaga; Keizo Sugimachi
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 418 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0008-543X
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## Abstract Vitamin D (VD) protects against colon carcinogenesis by mechanisms not fully understood. We had earlier reported on the similarity in the biologic action of VD and that of the calciumβsensing receptor (CaSR) in human colon carcinoma cells. At the molecular level, the CaSR gene contains