5-Aza-2′-deoxycytidine reactivates expression of RUNX3 by deletion of DNA methyltransferases leading to caspase independent apoptosis in colorectal cancer Lovo cells

5-Aza-2′-deoxycytidine induces p21WAF ex

5-Aza-2′-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia

✍ Karin Schmelz; Mandy Wagner; Bernd Dörken; Ingo Tamm 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 1005 KB

## Abstract The DNA methylation inhibitor 5‐Aza‐2′‐deoxycytidine (5‐Aza‐CdR) has significant therapeutic value for the treatment of patients with myelodysplastic syndrome (MDS), acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). The demethylating effect of 5‐Aza‐CdR has been well char