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5-Aza-2′-deoxycytidine induces retinoic acid receptor-β2 demethylation and growth inhibition in esophageal squamous carcinoma cells

✍ Scribed by Zhongmin Liu; Liyong Zhang; Fang Ding; Jie Li; Mingzhou Guo; Wendong Li; Yunhai Wang; Zaicheng Yu; Qimin Zhan; Min Wu; Zhihua Liu

Book ID: 116333582
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 326 KB
Volume: 230
Category: Article
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2005.01.012

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The expression of several cancer-related genes has been reported to be silenced by DNA methylation of their promoter region. 5-Aza-2-deoxycytidine (5-AZA-CdR), a potent and specific inhibitor of DNA methylation, can reactivate the in vitro expression of these genes. In future clinical trials in tumo