5- and 7-oxa trinems: their synthesis and biological evaluation

✍ Scribed by Daniele Andreotti; Tino Rossi; Carla Marchioro

• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 263 KB
• Volume: 6
• Category: Article
• ISSN: 0960-894X
• DOI: 10.1016/0960-894x(96)00477-5

✦ Synopsis

Introduction of the methoxy group at the allylic C-4 position of trinem 1 has mainly resulted in a remarkable enhancement of antimicrobial activity. A successful attempt in terms of antibacterial activity was made by introduction of an oxygen atom alternatively at the allylic position 5 and 7 of 1 In particular compounds 3 and 4 resulted of relevant interest.