5-Aminopyrazoles from enolisable ketones and 1-cyano-1-alkylhydrazines.

✍ Scribed by Thomas Ryckmans; Heinz-Gunter Viehe; Janine Feneau-Dupont; Bernard Tinant; Jean-Paul Declerco

• Book ID: 104207444
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 453 KB
• Volume: 53
• Category: Article
• ISSN: 0040-4020
• DOI: 10.1016/s0040-4020(96)01074-5

✦ Synopsis

The reaction of enolisable ketones with I-alkyl-1-cyanohydraziaes leads to the corresponding cyanohydrazones. These compounds cyclise under thermal or mildly basic conditions, furnishing the corresponding 5-aminopyrazoks in gocd yield. In some cases, the hydrazones cannot be isolated, and the pyrazole derivatives are directly obtained. Hydrazone-enebydmzine tautomerism was observed, but no subsequent [3,31 reammgemettt.