Protoporphyrin IX (Pp IX) is the main photosensitizer in photochemotherapy with 5-aminolevulinic acid (ALA). Pp IX is photolabile and the present work shows that 70-95% of Pp IX in cells is degraded by clinically relevant light exposures (40-200 J cm 22 at 630 nm). During light exposure a small yiel
5-Aminolevulinic acid ester–induced protoporphyrin IX in a murine melanoma cell line
✍ Scribed by Flavia C. B. Vena; Rozane F. Turchiello; Isabelle Laville; Sophie Pigaglio; Jocelyne Blais; Antonio C. Tedesco
- Book ID
- 106274383
- Publisher
- Springer-Verlag
- Year
- 2004
- Tongue
- English
- Weight
- 258 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0268-8921
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When 5-aminolevulinic acid ( ALA ) is administered topically, intravenously or intraperitoneally to tumor-bearing animals or humans, tumor selective production of protoporphyrin IX ( PpIX ) is frequently observed. Several biophysical, biochemical and physiological factors explain this tumor selectiv
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