5-Amidinoindoles as Dual Inhibitors of Coagulation Factors IXa and Xa.
β Scribed by Douglas G. Batt; Jennifer X. Qiao; Dilip P. Modi; Gregory C. Houghton; Deborah A. Pierson; Karen A. Rossi; Joseph M. Luettgen; Robert M. Knabb; P. K. Jadhav; Ruth R. Wexler
- Book ID
- 101964119
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 17 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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## Abstract For Abstract see ChemInform Abstract in Full Text.
## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a βFull Textβ option. The original article is trackable v
The coagulation cascade enzymes thrombin and factor Xa are known to have specificity pockets very similar to those of trypsin and plasmin. However, comparative molecular modeling analysis of the crystal structures of benzamidine-thrombin and benzamidine-trypsin, in conjunction with a docking analysi