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5 Acid-Induced Stimulation of the NHE2 Promoter Activity is Mediated by Transcription Factor EGR-1 in the Human Intestinal Epithelial Cell Line C2BBe1

โœ Scribed by Saminathan Muthusamy; Ming Cheng; Jong Jin Jeong; Pradeep K. Dudeja; Jaleh Malakooti


Book ID
119432850
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
182 KB
Volume
142
Category
Article
ISSN
0016-5085

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Background: High levels of proinflammatory cytokines are linked to pathogenesis of diarrhea in inflammatory bowel disease (IBD). Na รพ absorption is compromised in IBD. The studies were designed to determine the effect of tumor necrosis factor-a (TNFa) on the expression and activity of NHE2, a Na รพ /