5-(4′-Methylbiphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole
✍ Scribed by Wang, Guo-Xi ;Ye, Heng-Yun
- Book ID
- 104492066
- Publisher
- International Union of Crystallography
- Year
- 2007
- Tongue
- English
- Weight
- 647 KB
- Volume
- 63
- Category
- Article
- ISSN
- 1600-5368
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✦ Synopsis
The title compound, C~33~H~26~N~4~, was synthesized in two steps from 2-phenylbenzonitrile. Geometric parameters are in the usual ranges. The tetrazole ring encloses dihedral angles of 45.76 (9), 71.44 (8) and 72.38 (6)° with the three phenyl rings of the triphenylmethyl group. The dihedral angle between the tetrazole ring and the benzene ring directly attached to it is 49.13 (8)° and the dihedral angle between the aromatic rings of the biphenyl group is 54.29 (8)°.
📜 SIMILAR VOLUMES
Practical synthesis of 5-(4'-methylbiphenyl-2-yl)-1H-tetrazole, key intermediate in several angiotensin II receptor antagonists from 2-fluorobenzonitrile in excellent yields and very high purity is described.
The title compound, C 33 H 25 BrN 4 , belongs to the class of substituted tetrazoles. This type of compound is an important starting material for the synthesis of pharmaceutically active materials.