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5-[1‘-(2‘- N -Arylsulfonyl-1‘,2‘,3‘,4‘-tetrahydroisoquinolyl)]-4,5-dihydro-2(3 H )-furanones: Positive Allosteric Modulators of the GABA A Receptor with a New Mode of Action

✍ Scribed by Razet, Rodolphe; Thomet, Urs; Furtmüller, Roman; Chiaroni, Angèle; Sigel, Erwin; Sieghart, Werner; Dodd, Robert H.

Book ID: 126833068
Publisher: American Chemical Society
Year: 2000
Tongue: English
Weight: 72 KB
Volume: 43
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm001049i

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## Abstract 3,4‐Dichloro‐2(5__H__)‐furanone, which has been prepared efficiently from mucochloric acid, has been transformed selectively into 4‐aryl‐3‐chloro‐2(5__H__)‐furanones either by Suzuki‐ or Stille‐type reactions. These monochloro derivatives have been used as precursors either to (__Z__)‐4