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4981868 Pharmaceutically active 3-heteroaryl-2-fluoro 1-olefins

โœ Scribed by Amsel, Eric; Johnston, Adam


Book ID
122424683
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
81 KB
Volume
22
Category
Article
ISSN
0306-3623

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FC(SiMe3)3 and FC(SiMe3)2SnBu3: a novel
โœ Masaki Shimizu; Takeshi Hata; Tamejiro Hiyama ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 231 KB

Reaction of fluorotris(trimethyisilyl)methane and aldehydes is catalyzed by KF/18-Cr-6 to give 1,3disubstituted 2-fluoro-2-propen-l-ols in one pot. On the other hand, Sn-Li exchange of bis(trimethylsilyl)fluoro(tributylstannyl)methane with BuLi and subsequent treatment with an aldehyde afforded 1flu