Short DNA fragments induce site specific
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Katharina Hunger-Bertling; Petra Harrer; Wolf Bertling
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Article
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1990
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Springer
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English
β 767 KB
A defective hprt gene was corrected by homologous recombination in a lymphocyte cell line deficient in Hypoxanthine-phosphoribosyl-transferase activity (hprt). In a novel approach, only a fragment of a cDNA clone of the functional hprt gene was used to induce homologous recombination. The mutation t