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491: Interaction of Hedgehog-Gli and estrogen receptor signaling pathways in breast cancer cells

✍ Scribed by Levanat, S.; Trnski, D.; Uzarevic, Z.; Ozretic, P.; Musani, V.; Sabol, M.

Book ID
125800895
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
72 KB
Volume
50
Category
Article
ISSN
0959-8049

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The responsiveness of estrogen receptor (ER)-positive breast cancer to endocrine therapy is frequently reduced in cells over-expressing c-erbB-2. Stimulation of ER suppresses c-erbB-2, indicating that estrogen controls the activity of c-erbB-2. Heregulin (HRG) has been described to bind to c-erbB-3/