49. Phase separation of protein solutions during freezing: A confocal Raman microscopy study
โ Scribed by Jinping Dong; Allison Hubel; John C. Bischof; Alptekin Aksan
- Book ID
- 116392970
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 45 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0011-2240
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Phase separation in amorphous freeze-dried proteins systems is speculated to occur, but limitations in methods of detection have hindered progress in identifying and studying this phenomenon. We present here preliminary results obtained on model two-component protein-stabilizer systems that illustra
The freezing process is a source of product instability in many freeze-dried pharmaceuticals. During freezing, the solute is concentrated in the interstitial spaces between ice crystals, and phase separation may occur, with likely negative stability implications. Phase separation may involve crystal