Protein kinase C (PKC), a family of serine-threonine kinases, rocketed to the forefront of the cancer research field in the early 1980βs with its identification as an effector of phorbol esters, natural products with tumor promoting activity. Phorbol esters had long been of interest to the cancer re
β¦ LIBER β¦
485 Targeting the MAP Kinase and Wnt Signaling Pathways in Preclinical Models of Colorectal Cancer
β Scribed by Spreafico, A.; Klauck, P.J.; Tentler, J.J.; Pitts, T.M.; Tan, A.C.; Kim, J.; Gregory, M.A.; McManus, M.C.; Arcaroli, J.J.
- Book ID
- 123503745
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 60 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0959-8049
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## Abstract It is unclear whether the mutation spectra in WNT genes vary among distinct types of colorectal tumors. We have analyzed mutations in specific WNT genes in a cohort of 52 colorectal tumors and performed a metaβanalysis of previous studies. Notably, significant differences were found amo