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479. Expression of the apoptosis inhibitors p53, bcl-2, EGFR and survivin in renal cell carcinomas: Correlation with pathological features and clinical outcome

✍ Scribed by Contis, J.; Lykoudis, P.; Nastos, C.; Karakatsanis, A.; Dellaportas, D.; Delis, A.; Karandrea, D.; Pafiti-Kondi, A.

Book ID: 126698035
Publisher: Elsevier Science
Year: 2014
Tongue: English
Weight: 25 KB
Volume: 40
Category: Article
ISSN: 0748-7983
DOI: 10.1016/j.ejso.2014.08.485

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## Abstract ## Background. The p53 protein, a well‐known tumor suppressor that functions primarily as a transcription factor, initiates cell cycle arrest and apoptosis after genotoxic stress. The antiapoptotic regulator Bcl‐2 is a downstream modulator of p53‐induced apoptosis. Loss of function of