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4788149 Proteolytic enzyme from blood-sucking nematodes and its uses as an anticoagulant as a vaccine and as an antithelminic agent


Book ID
123195858
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
45 KB
Volume
7
Category
Article
ISSN
0734-9750

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Enzyme specificity and tissue distributi
โœ Shoji Takakura; Hideaki Minoura; Yukinori Shimoshige; Kyoko Minoura; Ikuo Kawamu ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 146 KB

## Abstract The enzyme specificity and tissue distribution of zenarestat, an aldose reductase inhibitor, was investigated in diabetic rats. Zenarestat inhibited both rat sciatic nerve aldose reductase (AR) activity and recombinant human AR with IC~50~ values of 7.5 and 44 nM, respectively. However,