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4,6,4′-Trimethylangelicin induces interstrand cross-links in mammalian cell DNA

✍ Scribed by F. Bordin; C. Marzano; C. Gatto; F. Carlassare; P. Rodighiero; F. Baccichetti

Book ID
108044138
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
511 KB
Volume
26
Category
Article
ISSN
1011-1344

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## Abstract Interstrand cross‐links (ICLs) are among the most cytotoxic DNA lesions to cells because they prevent the two DNA strands from separating, thereby precluding replication and transcription. Even though chemotherapeutic cross‐linking agents are well established in clinical use, and numero