456 THE IMPACT OF LOW DENSITY LIPOPROTEIN RECEPTOR (LDLR) GENE MUTATION ON CAROTID INTIMA MEDIA THICKNESS, IN PATIENTS WITH FAMILIAL HYPERCHOLESTEROLEMIA
β Scribed by Metaxa, V.; Pitsavos, C.; Skoumas, I.; Miliou, A.; Oikonomou, E.; Aznaouridis, K.; Masoura, K.; Stefanadis, C.
- Book ID
- 118639463
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 42 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1567-5688
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Heterozygous familial hypercholesterolemia (FH) is a relatively common autosomal dominant disorder, which is characterized by elevated plasma concentrations of low density lipoprotein (LDL) cholesterol and early coronary heart disease. FH results from mutations in the gene encoding the LDL receptor
Elevated blood plasma cholesterol (hypercholesterolemia) is a major risk factor for coronary artery disease (CAD) in humans. Genetic dissection of polygenic lipid and lipoprotein disorders in swine, a key animal model for the study of familial hypercholesterolemia (FH) and CAD, led to the isolation