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45 RAPID AND EFFICIENT ANTIGEN PROCESSING AND PRESENTATION OF A PROTECTIVE AND IMMUNODOMINANT HLA-B*27-RESTRICTED HEPATITIS C VIRUS-SPECIFIC CD8+ T CELL EPITOPE

✍ Scribed by J. Schmidt; A.K.N. Iversen; S. Tenzer; E. Gostick; D.A. Price; V. Lohmann; P. Bowness; H. Schild; H.E. Blum; P. Klenerman; C. Neumann-Haefelin; R. Thimme


Book ID
117380259
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
67 KB
Volume
56
Category
Article
ISSN
0168-8278

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Human leukocyte antigen B27 (HLA-B27) is associated with protection in human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infection. This protective role is linked to single immunodominant HLA-B27-restricted CD8+ T-cell epitopes in both infections. In order to define the relative contrib