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45. Fatigue in spinal muscular atrophy and spinobulbar muscular atrophy patients: Evidence of activity-dependent conduction block

✍ Scribed by Yu-ichi Noto; Kazuaki Kanai; Sonoko Misawa; Kazumoto Shibuya; Sagiri Isose; Saiko Nasu; Yukari Sekiguchi; Yumi Fujimaki; Shigeki Ohmori; Masanori Nakagawa; Satoshi Kuwabara


Book ID
116371551
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
39 KB
Volume
123
Category
Article
ISSN
1388-2457

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In vivo activation of SMN in spinal musc
✍ Lars Brichta; Irmgard Holker; Karsten Haug; Thomas Klockgether; Brunhilde Wirth πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 279 KB πŸ‘ 2 views

## Abstract ## Objective Spinal muscular atrophy results from loss of the survival motor neuron 1 (__SMN1__) gene and malfunction of the remaining __SMN2__. We investigated whether valproic acid can elevate human __SMN__ expression in vivo. ## Methods Blood was collected from 10 spinal muscular