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448 Age-related amyloid β protein accumulation induces cellular death and macrophage activation

✍ Scribed by M. Shoji; T. Kawarabayashi; Y. Igeta; Y. Tomidokoro; K. Ishiguro; E. Matsubara; K. Okamoto


Book ID
117414001
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
261 KB
Volume
17
Category
Article
ISSN
0197-4580

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In view of the importance of amyloid beta protein accumulation in Alzheimer's disease, this paper examines age-related amyloid beta protein (Abeta) deposition and accompanying cellular changes in a mouse model in vivo. Transgenic mice were studied which expressed a gene encoding 18 residues of signa