4,4′-Disubstituted L-Prolines as Highly Enantioselective Catalysts for Direct Aldol Reactions
✍ Scribed by Liuqun Gu; Menglong Yu; Xiaoyu Wu; Yazhu Zhang; Gang Zhao
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 108 KB
- Volume
- 348
- Category
- Article
- ISSN
- 1615-4150
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## Abstract The CoCl~2~/L‐proline (1:2) system was found to be an excellent catalyst for direct aldol reactions. Excellent yields (up to 93 %) and a significant improvement in diastereoselectivity (__anti__/__syn__ up to 45:1) as well as enantioselectivity (up to more than 99 % __ee__) compared wit
## Abstract Proline catalysis of the asymmetric direct aldol reaction involves both the secondary amine function and the carboxyl group of the amino acid. __N__‐Sulfonylcarboxamides are known to be of similar acidity as carboxylic acids, and three __N__‐arylsulfonyl derivatives of L‐proline amide w