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4,4′-Disubstituted L-Prolines as Highly Enantioselective Catalysts for Direct Aldol Reactions

✍ Scribed by Liuqun Gu; Menglong Yu; Xiaoyu Wu; Yazhu Zhang; Gang Zhao


Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
108 KB
Volume
348
Category
Article
ISSN
1615-4150

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## Abstract The CoCl~2~/L‐proline (1:2) system was found to be an excellent catalyst for direct aldol reactions. Excellent yields (up to 93 %) and a significant improvement in diastereoselectivity (__anti__/__syn__ up to 45:1) as well as enantioselectivity (up to more than 99 % __ee__) compared wit

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