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4,4′-Dichlorobiphenyl: Distribution, metabolism, and excretion in the dog and the monkey

✍ Scribed by I.G. Sipes; M.L. Slocumb; D.F. Perry; D.E. Carter


Book ID
113205430
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
802 KB
Volume
55
Category
Article
ISSN
0041-008X

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35S-Furosemide was administered to beagle dogs and rhesus monkeys in an oral solution on a single and a 20 repeated 5-mg/kg/day dosing regimen. Following the single dose, 25.0% (dogs) and 24.0% (monkeys) of the dose were excreted in the urine in 24 hr. TLC analysis demonstrated that both species had