4385054 1-Acetoxyethyl-3-(2-chloroethylcarba-moyloxymethyl)-7-(2-(fur-2-yl)-2- methoxyiminoacetamido) meph-3-em-4-carboxylate
- Book ID
- 122774453
- Publisher
- Elsevier Science
- Year
- 1983
- Tongue
- English
- Weight
- 57 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0306-3623
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📜 SIMILAR VOLUMES
## Abstract The title compound 9 was prepared by the route outlined in Scheme I. [^14^C]Thiourea (1) was condensed with ethyl 4‐bromo‐3‐oxo‐2‐methoxyiminoacetate (2), providing ethyl 2‐(2‐amino‐4‐[2‐^14^C]thiazolyl)‐2‐methoxyiminoacetate (3), as the pure Z‐isomer. Saponification gave the amino acid
1-(Cyclohexyloxycarbony1oxy)ethyl 7P-[2-(2-aminothiazol-~-yl~acetamido]-3-[[[1-(2-dimethylaminoethyl~-1H-tetrazol-~-yl]thio]methyl]ceph-3-em-4-carboxylate dihydrochloride (SCE-2174), a new orally active cephalos orin, was labeled with carbon-14 starting from [l-lgC] c yc lohexanol (1) . 1 -Chloroe t
## Abstract (6R,7R)‐7‐[2‐(5‐amino‐1,2,4‐thiadiazol‐3‐yl)‐(Z)‐2‐methoxyiminoacetamido]‐3‐[4‐(carbamoyl‐1‐quinuclidinio)methyl]ceph‐3‐em‐4‐carboxylate (E1040), a new injectable cephalosporin with potent antipseudomonal activity, was synthesized labelled with carbon‐14, starting from potassium [^14^C]