422 Investigation of the Apoptotic Pathways Activated by Equol and Tamoxifen in MCF-7 Breast Cancer Cells
โ Scribed by C. Charalambous; A.I. Constantinou
- Book ID
- 117662941
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 72 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0959-8049
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## Abstract Febrile hyperthermia enhanced TNFโstimulated apoptosis of MCFโ7 cells and overcame resistance in a TNFโresistant, MCFโ7 variant (3E9), increasing their TNFโsensitivity by 10โ and 100โfold, respectively. In either cell line, the hyperthermic potentiation was attributable to increased apo
We report here that the antiestrogen tamoxifen (TAM) induces cell death in human breast cancer cell line MCF-7. We assessed the type of cell death induced by TAM in this breast cancer cell line on the basis of morphological and biochemical characteristics. Dying cells showed morphological characteri