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410 Correlation between BLC-2 protein expression and the clinical, pathological and biological characteristics of 483 breast cancer patients

✍ Scribed by R. Pedersini; M. Frisinghelli; M. Giovannini; M. Pavarana; R. Micciolo; F. Bonetti; Q. Piubello; F. Battistelli; G.L. Cetto; A. Molino


Book ID
118620584
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
181 KB
Volume
1
Category
Article
ISSN
1359-6349

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Correlation of CHEK2 protein expression
✍ Outi Kilpivaara; Jirina Bartkova; Hannaleena Eerola; Kirsi SyrjΓ€koski; Pia Vahte πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 French βš– 145 KB

The CHEK2 kinase is a tumor suppressor whose activation in response to DNA double-strand breaks contributes to cell cycle arrest or apoptosis. The c.1100delC mutation is associated with familial breast cancer, and tumors from mutation carriers show reduced or absent CHEK2 protein expression. We have