𝔖 Bobbio Scriptorium
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41. The B cell defect in hyper IgM immunodeficiency (dysgammaglobulinemia)

✍ Scribed by ROSEN, F; ALAMI, S; FARAH, F; HYSLOP, N; SCHNEEBERGER, E; GEHA, R


Book ID
119055504
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
296 KB
Volume
61
Category
Article
ISSN
1097-6825

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Mott cells are a variant form of plasma cell in which the immunoglobulin (Ig), rather than being secreted, accumulates in rough endoplasmic reticulum-derived vesicles called Russell bodies. We have examined the molecular cause of this defect and the in vivo origin of IgM Mott cells. Our examination