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4-Substituted-8-(1-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with superior pharmacological and pharmacokinetic parameters

✍ Scribed by Daniela Alberati; Dominik Hainzl; Synèse Jolidon; Anke Kurt; Emmanuel Pinard; Andrew W. Thomas; Daniel Zimmerli

Book ID: 108074050
Publisher: Elsevier Science
Year: 2006
Tongue: English
Weight: 132 KB
Volume: 16
Category: Article
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2006.05.063

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

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Design and Synthesis of 4-Substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4,5]decan-1-one as a Novel Class of GlyT1 Inhibitors: Achieving Selectivity Against the μ Opioid and Nociceptin/Orphanin FQ Peptide (NOP) Receptors.

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