4-Methylpyrazole blocks acetaminophen hepatotoxicity in the rat
β Scribed by Richard J. Brennan; Russell F. Mankes; Rene Lefevre; Nancy Raccio-Robak; Robert H. Baevsky; James A. DelVecchio; Brian J. Zink
- Book ID
- 108420843
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 543 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1097-6760
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Cimetidine has been shown to protect against acetaminophen-mediated hepatotoxicity in both rats and mice. In contrast to cimetidine, ranitidine recently has been determined to potentiate the hepatotoxic action of acetaminophen in Fischer 344 rats. The present studies were designed to characterize th
Acetaminophen is a mild analgesic and antipyretic agent known to cause centrilobular hepatic necrosis at toxic doses. Although this may be due to a direct interaction of reactive acetaminophen metabolites with hepatocyte proteins, recent studies have suggested that cytotoxic mediators produced by pa