𝔖 Bobbio Scriptorium
✦   LIBER   ✦

4-Methylpyrazole blocks acetaminophen hepatotoxicity in the rat

✍ Scribed by Richard J. Brennan; Russell F. Mankes; Rene Lefevre; Nancy Raccio-Robak; Robert H. Baevsky; James A. DelVecchio; Brian J. Zink


Book ID
108420843
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
543 KB
Volume
23
Category
Article
ISSN
1097-6760

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Ranitidine-acetaminophen interaction: Ef
✍ Thomas B. Leonard; D. Gwyn Morgan; John G. Dent πŸ“‚ Article πŸ“… 1985 πŸ› John Wiley and Sons 🌐 English βš– 970 KB

Cimetidine has been shown to protect against acetaminophen-mediated hepatotoxicity in both rats and mice. In contrast to cimetidine, ranitidine recently has been determined to potentiate the hepatotoxic action of acetaminophen in Fischer 344 rats. The present studies were designed to characterize th

Role of nitric oxide in acetaminophen-in
✍ Carol R. Gardner; Diane E. Heck; Chung S. Yang; Paul E. Thomas; Xu-Jie Zhang; Ge πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 199 KB πŸ‘ 2 views

Acetaminophen is a mild analgesic and antipyretic agent known to cause centrilobular hepatic necrosis at toxic doses. Although this may be due to a direct interaction of reactive acetaminophen metabolites with hepatocyte proteins, recent studies have suggested that cytotoxic mediators produced by pa