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4-Hydroxyphenylretinamide (4HPR) derivatives regulate aromatase activity and expression in breast cancer cells

✍ Scribed by Bin Su; Serena M. Mershon; Laura A. Stonerock; Robert W. Curley Jr.; Robert W. Brueggemeier


Book ID
116698147
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
624 KB
Volume
109
Category
Article
ISSN
0960-0760

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Fenretinide, 4-(N-hydroxyphenyl) retinamide (4-HPR), has demonstrated anticancer activity associated with a favorable toxicity profile and is now being investigated in several clinical trials. However, its plasma levels in patients have been far lower than the effective concentration required to ind