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4-Hydroxymethyl-1,6,8-trimethylfuro[2,3- h ]quinolin-2(1 H )-one Induces Mitochondrial Dysfunction and Apoptosis upon Its Intracellular Oxidation

โœ Scribed by Chilin, Adriana; Dodoni, Giuliano; Frezza, Christian; Guiotto, Adriano; Barbieri, Vera; Di Lisa, Fabio; Canton, Marcella


Book ID
120651194
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
413 KB
Volume
48
Category
Article
ISSN
0022-2623

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An asymmetric synthesis of (R)-5-(methyl
โœ Richard F. Heier; Malcolm W. Moon; Wayne T. Stolle; John A. Easter; Richard S. P ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 569 KB

## ~R~ 5, quinolin-2( lm-one (1) is a dopamine agonist which shows selectivity for the D2 receptor subtype, and is of interest as a potential drug for the treatment of Parkinson's disease. An asymmetric epoxidation approach has been used to prepare 1 in eleven steps (15% overall yield) from 8-nit