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4-Hydroxyisovaleric acid: A new metabolite in isovaleric acidemia

✍ Scribed by W. Lehnert; H. Niederhoff


Book ID
104776198
Publisher
Springer
Year
1981
Tongue
English
Weight
158 KB
Volume
136
Category
Article
ISSN
0340-6997

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2-hydroxy-4-trifluoromethylbenzoic acid (HTB) is the main active metabolite of the platelet antiaggregant drug triflusal. Its binding to plasma proteins of rats and healthy volunteers in vitro and in vivo has been studied. Rats were given a single oral dose of 50 mg.kg-1 triflusal and the healthy vo