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4-Hydroxyisoleucine: effects of synthetic and natural analogues on insulin secretion

✍ Scribed by Christophe Broca; Michèle Manteghetti; René Gross; Yves Baissac; Marc Jacob; Pierre Petit; Yves Sauvaire; Gérard Ribes

Book ID
114012811
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
398 KB
Volume
390
Category
Article
ISSN
0014-2999

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Multi-Step Synthesis and Biological Eval
Multi-Step Synthesis and Biological Evaluation of Analogues of Insulin Secretagogue (2S,3R,4S)-4-Hydroxyisoleucine
✍ Kaïss Aouadi; Anne-Dominique Lajoix; René Gross; Jean-Pierre Praly 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 440 KB 👁 1 views

## Abstract A series of stereochemically defined analogues of (2__S__,3__R__,4__S__)‐4‐hydroxyisoleucine and related α‐hydroxy acids have been prepared by multi‐step routes from D‐glucose, whereas ketolization between TBDMS‐protected hydroxypropanone and ethyl isocyanoacetate led to racemic analogu