4-Hydroxyandrostenedione in the prophylaxis of N-methyl-N-nitrosourea induced mammary tumourigenesis
β Scribed by Coombes, RC; Wilkinson, JR; Bliss, JM; Shah, P; Easton, DF; Dowsett, M
- Book ID
- 109836606
- Publisher
- Nature Publishing Group
- Year
- 1991
- Tongue
- English
- Weight
- 625 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0007-0920
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Rodents are susceptible to the effects of chemical carcinogens and have been widely used in the study of mammary-gland carcinogenesis. However, little information is available regarding specific phenotypic changes that occur during mammary-gland carcinogenesis. In this study, subtraction hybridizati
## Abstract The occurrence of Haβ__ras__ and Kiβ__ras__ oncogenes was investigated in mammary tumors produced by treating genetically resistant Copenhagen (Cop) rats with __N__βmethylβ__N__βnitrosourea. G^35^A codon 12 mutations in both Haβ__ras__ and Kiβ__ras__ genes were analyzed by a polymerase
Mammary tumors were induced in 48-52-day-old female Sprague-Dawley rats in metestrus or diestrus with a single jugular injection of MNU (50 mg/kg). Control rats received the saline vehicle (Group 4 n Ο 9). Rats were fed 4% Teklad diet containing either 0 (Group 3, n Ο 20) or 782 mg 4-HPR/kg diet. 4-