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4-Hydroxy-6-methoxyaurones with High-Affinity Binding to Cytosolic Domain of P-Glycoprotein.

✍ Scribed by Ahcene Boumendjel; Chantal Beney; Nabajyoti Deka; Anne-Marie Mariotte; Martin Ata Lawson; Doriane Trompier; Helene Baubichon-Cortay; Attilio Di Pietro

Book ID
101936541
Publisher
John Wiley and Sons
Year
2010
Weight
29 KB
Volume
33
Category
Article
ISSN
0931-7597

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P-glycoprotein (P-gp) is a plasma membrane glycoprotein that confers multidrug resistance on cells by virtue of its ability to exclude cytotoxic drugs in an ATP-dependent manner. The most commonly considered hypothesis is that P-gp acts as an ATP-driven drug-export pump, the mechanism of which is no