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4-hydroxy-2-quinolones. 42. Synthesis and biological activity of 1-R-2-oxo-3-(2H-1,2,4-benzothiadiazine-1,1-dioxid-3-yl)-4-hydroxyquinolines

✍ Scribed by I. V. Ukrainets; E. A. Taran; O. V. Gorokhova; N. A. Jaradat; L. N. Voronina; I. V. Porokhnyak

Publisher: Springer US
Year: 2000
Tongue: English
Weight: 262 KB
Volume: 36
Category: Article
ISSN: 0009-3122
DOI: 10.1007/bf02256875

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Efficient synthesis of 4,4-disubstituted

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A simple method for the preparation of 4,4-disubstituted-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2dioxides is described. Treatment of N-sulfonyl ketimines 2 and 3 with different carbon nucleophiles afforded the corresponding of 4,4-disubstituted-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxides 1 i