4-Hydroxy-1-[2-(4-hydroxyphenoxy)ethyl]-4-(4-methylbenzyl)piperidine: A Novel, Potent, and Selective NR1/2B NMDA Receptor Antagonist
โ Scribed by Zhou, Zhang-Lin; Cai, Sui Xiong; Whittemore, Edward R.; Konkoy, Christopher S.; Espitia, Stephen A.; Tran, Minhtam; Rock, David M.; Coughenour, Linda L.; Hawkinson, Jon E.; Boxer, Peter A.; Bigge, Christopher F.; Wise, Lawrence D.; Weber, Eckard; Woodward, Richard M.; Keana, John F. W.
- Book ID
- 119940748
- Publisher
- American Chemical Society
- Year
- 1999
- Tongue
- English
- Weight
- 129 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-2623
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๐ SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
Antagonists at the 1A/2B subtype of the NMDA receptor (NR1A/2B) are typically small molecules that consist of a 4-benzyl-or a 4-phenylpiperidine with an ฯ-phenylalkyl substituent on the heterocyclic nitrogen. Many of these antagonists, for example ifenprodil (1), incorporate a 4-hydroxy substituent
## Abstract In order to perform __in vivo__ imaging of the NR2B NMDA receptor system by positron emission tomography, a NR2B selective NMDA receptor antagonist has been labelled with carbonโ11 (halfโlife: 20โmin). __N__โ[4โ(4โfluorobenzyl)piperidinโ1โyl]โ__N__โฒโ(2โoxoโ1,3โdihydrobenzimidazolโ5โyl)o