Steroidal 3-carboxy-20-ketones have been prepared within two structural series, the androsta-3,5-dienes and the estra-1,3,5-trienes, as potential inhibitors of types 1 and 2 steroid 5 alpha-reductase, the enzyme activity responsible for the final step in biosynthesis of dihydrotestosterone. These co
✦ LIBER ✦
4-Aza-3-oxo-5α-androst-1-ene-17β- N -arylcarboxamides as Dual Inhibitors of Human Type 1 and Type 2 Steroid 5α-Reductases. Dramatic Effect of N -Aryl Substituents on Type 1 and Type 2 5α-Reductase Inhibitory Potency
✍ Scribed by Bakshi, Raman K.; Rasmusson, Gary H.; Patel, Gool F.; Mosley, Ralph T.; Chang, Benedict; Ellsworth, Kenneth; Harris, Georgianna S.; Tolman, Richard L.
- Book ID
- 127043087
- Publisher
- American Chemical Society
- Year
- 1996
- Tongue
- English
- Weight
- 44 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0022-2623
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