✦ LIBER ✦

[4-Amino-D-phenylalanine6]luliberin. A biologically active abalog of the luteinizing hormone-releasing factor suitable for affinity labeling

✍ Scribed by Constantinos Sakarellos; Bernard Donzel; Murray Goodman

Book ID: 101717292
Publisher: Wiley (John Wiley & Sons)
Year: 1976
Tongue: English
Weight: 349 KB
Volume: 15
Category: Article
ISSN: 0006-3525
DOI: 10.1002/bip.1976.360150916

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✦ Synopsis

Abstract

The syntheis of [4‐amino‐D‐phenylalanine^6^]luliberin by the solid‐phase method is described. The analog was found to be ten times more potent than luliberin. Some possibilities for the easy derivatization of the 4‐amino‐phenylalanyl residue into addinity labels suitable for the study of hormone‐receptor interations are considered. The preparation of N^α^‐t‐butyloxycarbonyl‐4‐(benzyloxycarbonylamino)‐D‐phenylalanine, one of the key intermediates used in the synthesis of this luliberin analog, is also reported.

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