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4-Amino-2,6-Dichlorophenol Nephrotoxicity in the Fischer 344 Rat: Protection by Ascorbic Acid, AT-125, and Aminooxyacetic Acid

โœ Scribed by Suk K. Hong; Dianne K. Anestis; John G. Ball; Monica A. Valentovic; Patrick I. Brown; Gary O. Rankin

Book ID
112266533
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
150 KB
Volume
147
Category
Article
ISSN
0041-008X

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โœ Jan L. Vansteenhouse; Judith S. Prescott; David H. Swenson ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 226 KB ๐Ÿ‘ 1 views

Cyano-3,4-epithiobutane (CEB), a naturally occurring nitrile derived from cruciferous plants, causes nephrotoxicity and increased renal glutathione (GSH) concentration in male F-344 rats. This CEBinduced nephrotoxicity is dependent on GSH conjugation and bioactivation. The objectives of the present