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4-Acylamino-6-arylfuro[2,3-d]pyrimidines: potent and selective glycogen synthase kinase-3 inhibitors

โœ Scribed by Yutaka Maeda; Masato Nakano; Hideyuki Sato; Yasushi Miyazaki; Stephanie L Schweiker; Jeffery L Smith; Anne T Truesdale


Book ID
108073369
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
310 KB
Volume
14
Category
Article
ISSN
0960-894X

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Efficient formation of 4,6-disubstituted
โœ Anand Mayasundari; Naoaki Fujii ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 339 KB

A concise synthesis of 4,6-disubstituted pyrrolo[2,3-d]pyrimidines is described. The key step involves the formation of an ether or thioether linkage along with concurrent ring closure in one-pot to yield the desired product in only two steps from a common intermediate. The reaction is chemoselectiv