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3T3 cell motility in the temperature range 33°C to 39°C

✍ Scribed by Thurston, G. ;Palcic, B.

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
491 KB
Volume
7
Category
Article
ISSN
0886-1544

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✦ Synopsis

The phenomena of mammalian cell motility in tissue culture is an integrated function of many cellular components. As such, cell motility is very sensitive to external stimuli and perturbation. In this article we report the effect of temperature in the range 33°C to 39°C on cell motility. For this 3T3 cells were plated in plastic tissue culture flasks. A large number of individual cells (60 per experiment) were tracked as a function of time by means of an automated device, the Cell Analyzer. The data show a peak in the average cell speed in the range 365°C to 38.5"C, falling off sharply at lower and higher temperatures. The average rate of cell motility closely correlates to the average cell proliferation rate in the range 33°C to 39°C.

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