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(3R,4aR,5S,6R)-6-Hydroxy-5-methylramulosin: A New Ramulosin Derivative from a Marine-Derived Sterile Mycelium.

✍ Scribed by Ahmed Atef El-Beih; Hikaru Kato; Tomihisa Ohta; Sachiko Tsukamoto


Publisher
John Wiley and Sons
Year
2007
Weight
12 KB
Volume
38
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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## Methyl 4-(5-nitro-1,3-dioxaspiro[5.5] undecan-5-yl)but-2-enoate 2, obtained from the palladium(0)-catalyzed reaction of a salt of 5-nitro-1,3-dioxane 1 with methyl g-bromocrotonate, was converted into the title piperidinone (ee 78%) in three steps.