(3R,4aR,5S,6R)-6-Hydroxy-5-methylramulosin: A New Ramulosin Derivative from a Marine-Derived Sterile Mycelium.
✍ Scribed by Ahmed Atef El-Beih; Hikaru Kato; Tomihisa Ohta; Sachiko Tsukamoto
- Publisher
- John Wiley and Sons
- Year
- 2007
- Weight
- 12 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Abstract
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## Methyl 4-(5-nitro-1,3-dioxaspiro[5.5] undecan-5-yl)but-2-enoate 2, obtained from the palladium(0)-catalyzed reaction of a salt of 5-nitro-1,3-dioxane 1 with methyl g-bromocrotonate, was converted into the title piperidinone (ee 78%) in three steps.
## Note X-Ray structure of (5S,8R,9R, 10s)~8,9,10-triacetoxy-3-acetyl-1,6-dioxa-3-azaspiro[4S]decane, a spiropyranose derivative