[3H]Tyr-D-Ser-Gly-Phe-Leu-Thr: A specific probe for the δ-opiate receptor subtype in brain membranes
✍ Scribed by Monique David; Claude Moisand; Jean-Claude Meunier; Jean-Louis Morgat; Gilles Gacel; Bernard P. Roques
- Book ID
- 115876985
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 157 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0014-2999
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## Abstract The introduction of bulky residue (s) in linear enkephalin‐related hexapeptides represents a new approach in the design of selective probes for δ‐opioid receptors, displaying the appropriate criteria to investigate biological and pharmacological properties of the assumed binding site (δ
## 3 In a previous work, the synthesis of [ HI Tyr-D-Thr-Gly-Phe-Leu-Thr (DTLET), a highly selective probe for 6 opioid receptors has been described. More recently, Az-DTLET (Tyr-D-Thr-Cly-Phe (pN 1-Leu-Thr) has been shown to be a specific and irreversible photoaffinity ligand for 6 opioid sites.